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EN
CRISPR/Cas9 technology introduced a C to A change at position 1022 (c.1022C>A) resulting in an alanine to glutamate substitution at amino acid 341 (p.A341E). Three additional silent mutations were identified. This is the most prevalent hypomorphic missense mutation in European individuals with glycosylphosphatidylinositol (GPI)-anchor biosynthesis deficiency. (J:299612)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
