CRISPR/Cas9 technology using sgRNAs CCTTAGTATGTGATATACCTCAA and CCCGTACTCTTGTTCTAGGATGC deleted the entire gene complex. PCR and Northern blot analysis confirmed the absence of expression upon paternally inherited deletion, while expression remains unaffected upon maternal transmission of the allele. (J:305741)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x CBA)F1
Endonuclease-mediated
Intergenic deletion
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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