CRISPR/cas9 genome editing is used to insert a floxed STOP cassette (including a neomycin resistance cassette), an SV40 T antigen coding region, an internal ribosome entry site (IRES), and an enhanced green fluorescent protein (EGFP) sequence into the endogenous Gt(ROSA)26Sor locus. (J:305948)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x SJL)F1
Endonuclease-mediated
Insertion
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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