CRISPR/cas9 genome editing is used to insert a floxed STOP cassette (including a neomycin resistance cassette), an SV40 T antigen coding region, an internal ribosome entry site (IRES), and an enhanced green fluorescent protein (EGFP) sequence into the endogenous Gt(ROSA)26Sor locus. (J:305948)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count