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The allele was created to have the human BEST1 promoter/enhancer regions directing the expression of a CreER(T2) fusion gene. The targeting vector contained, from 5' to 3', the human BEST1 promoter (nucleotides -585 to +38), followed by a CreER(T2) fusion gene, and an SV40 a polyA cassette. The plasmid was pronuclear injected into C57BL/6J(attPx3) zygotes along with phiC31 integrase mRNA. The resulting founder mice were bred with C57BL/6J for germline transmission. (J:305495)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
