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Exon 3 and exon/intron 4 were targeted with two sgRNAs using CRISPR/Cas9 technology, resulting in a 1966 bp deletion, encompassing most of exon 3 (which contains the ATG start site) and the entirety of intron 3 and exon 4, and 4 bp insertion. Immunoblots confirmed the absence of peptide expression from this allele in the brain. (J:285485)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
