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The transgenic construct contains 2 copies of a chicken HS4 insulator sequence, a CMV enhancer/chicken beta-actin (CAG) promoter, full length a hemaglutatin (HA) tagged human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (hACE2) cDNA, and 2 more copies of the chicken HS4 insulator. Founder lines GT5-027 and GT4-008 were generated. GT5-027 carries two copies of the transgene and was used in experiments. High expression levels are detected in lung, kidney and brain. (J:305559)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
