A PGK-neo selection cassette flanked by FRT sites was inserted downstream of exon 1, and exon 1 was flanked by loxP sites. The targeted locus was deleted via Cre- amd FLP-mediated recombination. (J:304810)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count