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A BAC targeting construct harbouring the mouse Tardpb locus (BAC B6Ng01-103M13) was engineered to replace the gene from the ATG start site to the TAG stop codon with the orthologous human TARDBP genomic sequence derived from a BAC with the human TARDPB locus (BAC RP11-829B14), and an FRT-flanked PGK/gb2/Neo cassette was inserted into intron 3 of the human gene. Flp-mediated recombination removed the selection cassette. (J:342505)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
