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CRISPR-targeting modified exon 16 to humanize the sequence with the amino acid substitutions glycine to arginine at position 676, phenylalanine to tyrosine at position 681, and arginine to histidine at position 684 (G676R, F681Y, R684H) analogous to the Alzheimer's disease associated human mutations KM670/671NL, E693G, I716F. (J:303244)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
