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The transgenic construct contains a codon-optimized flp recombinase followed by a bGH polyadenylation (polyA) sequence under the direction of the murine heat shock response element (Hspa1b, formerly Hsp70-1) promoter/enhancer sequences .Founder line A4 was then selected for consistent expression. Analysis using shallow whole-genome sequencing suggests that the transgene integrated into an intronic region of the Tcerg locus on chromosome 18, and in the opposite orientation to the surrounding region. (J:303219)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
