The targeting vector is designed to insert a loxP site upstream of exon 2, and a second loxP site followed by an FRT-flanked PGK-neo cassette just downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo. (J:253684)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count