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CRISPR/cas9 mediated recombination created a deletion in exon 1. Using the forward primer TGAAGCATCCCAAGAAATCC and the reverse primer CACAGTCCTGTCCTGGTGTG the sequence remaining in the targeted region is GCACACTGCCTCTGAGATGA. Expression is reduced by more than 90% in cultured adult dorsal root ganglion cells from homozygous mice. (J:268832)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
