LoxP sites were inserted to flank exons 1-4 and an frt-flanked neomycin selection cassette. Exons 1-4 and the the neomycin selection cassette were removed via Cre-mediated recombination in the germline. (J:290931)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count