Log In|Sign Up
EN
A G-to-T mutation was engineered using crRNA, tracrRNA and an ssODN template with CRISPR/Cas9 technology. The c.442G>T mutation changes aspartic acid codon 148 to a tyrosine codon (p.Asp148Tyr), mimicking a mutation found in FINCA (fibrosis, neurodegeneration, and cerebral angiomatosis) syndrome patients. (J:299152)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
