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Using EUCOMM targeting vector HTGR04002_Z_5_C06, the locus was targeted for conditional knockout. The vector inserts an FRT site flanked lacZ/neomycin resistance fusion gene cassette and a loxP site into intron 2 (chr13: 64223896 on build GRCm39) and a second loxP site into intron 3 (chr13: 64224681). The lacZ/neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 3 floxed. (J:301756)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
