LoxP sites were inserted 190 bp upstream and 220 bp downstream of exon 2. A FRT-flanked neomycin cassette was that was inserted further downstream of exon 2 was subsequently removed via FLP1-mediated recombination in the germline. (J:128713)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count