LoxP sites were inserted into the intron upstream of exon 5 (encoding the EGF domain) and downstream of exon 8 encoding the transmembrane domain (TM). Exons 5-8 were deleted via Cre-mediated recombination in the germline. (J:301708)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count