Four DNA base pair mutations in exon 1 were inserted to alter codons to encode a triple amino acid mutation [R3R4(G)K5(A)]. An frt-flanked neomycin selection cassette was removed via FLP1-mediated recombination. (J:243561)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count