LoxP sites were inserted flanking exons 4 and 5 and an frt-flanked neomycin resistance cassette was inserted downstream of exon 5. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:298758)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count