Log In|Sign Up
EN
A K1259T (nucleotide AAA to ACC) missense mutation that is homologous to the human K1270T mutation was introduced to exon 19 using CRISPR/Cas9 methodologies. A silent EcoRV site mutation used for genotyping was introduced downstream of K1270T, and 2 additional silent insertional mutations flank the K1270T mutation to prevent Cas9 activity on the repaired allele. (J:320991)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
