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The transgene contains the mouse gene with the amino acid substitution of glutamic acid for lysine at position 487 (E487K) driven by the ubiquitously-expressing CAG promoter. This mutation is the same as in the human Aldh2*2 polymorphism, which acts as a dominant-negative gene. Line 02 was generated. (J:170150)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
