A loxP site was inserted upstream of exon 4 and an FRT-flanked neomycin phosphotransferase expression cassette followed by a second loxP site were inserted downstream of exon 5. The neomycin cassette was removed via Flp-mediated recombination leaving exons 4-5 floxed. (J:276228)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count