The transgene included anti-sense myoglobin with a heart-specific myosin heavy-chain (MHC) promoter, which targeted only heart muscle but not skeletal muscle. Lines 4 and 10 was generated. The myoglobin concentrations in heart muscle of line 4 is 0.58 the wild type (WT) Mb concentration and of line 10 0.38 of the WT Mb concentration. (J:94077)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Applicable
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Insertion
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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