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A targeting vector, containing human PCSK9 cDNA under the control of a 2.34 kb mouse albumin promoter/enhancer and a floxed cassette containing cre recombinase cDNA under the control of a 698 bp testis-specific angiotensin converting enzyme promotor and neomycin phosphotransferase selection marker driven by the pol II promoter, was inserted into the endogenous locus. Flp-mediated recombination removed the floxed cre and neo cassette. (J:280156)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
