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The targeting vector replaced the D-Q52*01-J4 with the B1-8 promoter and the modified V-region of the M315 myeloma protein heavy chain (generated from the MOPC315 cell line) in which the Vlambda2 exon 2 was replaced with a synthetic Vlambda315 exon 2 containing the modification YST to FRN (residues 94-96; TACAGCACC to TTCAGAAAC) and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:282821)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
