A loxP site was introduced in intron 1 and the second together with a Frt-flanked hygromycin B selection marker cassette was inserted into intron 2. The selection cassette was deleted via FLP-mediated recombination in the germline. (J:275647)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count