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Using CRISPR/Cas9 technology, a G-to-A substitution (C-to-T on forward strand) was created in glutamic acid codon 360 (initially reported as 365) to change it to a lysine codom (p.E360K). The mutation is located in the PR/SET domain and leads to the loss of most of the enzyme's histone methyltransferase activity. As this allele was created in the C57BL/6 strain, it is based on the Prdm9dom2 allele. (J:280261)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
