Using sgRNAs and ssODN templates with CRISPR/Cas9 technology, the gene was changed to make the isotypic region resemble the human C4A gene: endogenous codon sequence for PCPVIH was changed to PCPVLD (p.I1120_H1121delLDins) (J:301308)
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Using sgRNAs and ssODN templates with CRISPR/Cas9 technology, the gene was changed to make the isotypic region resemble the human C4A gene: endogenous codon sequence for PCPVIH was changed to PCPVLD (p.I1120_H1121delLDins) (J:301308)