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The targeted locus contains a PGK-neo cassette flanked by two FRT sites and two LoxP sites at the limits of the region to be excised. The region to be deleted contains the first exon and its upstream region. The first exon and the PGK-neo cassette were removed by crossing with general deleter Cre mice. Western blot analysis confirmed the absence of protein expression in brain lysates from newborn homozygous mutant mice. (J:272122)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
