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An AC-to-CT mutation (GT-to-AG on forward strand) was engineered in exon 18, which changes aspartic acid codon 664 to an alanine codon (p.D664A). This mutation prevents cleavage of the encoded peptide at the aspartate residue by caspases or caspase-like proteases. The loxP and FRT site flanked neomycin resistance gene cassette that was inserted downstream of exon 18 was deleted through subsequent flp-mediated recombination. (J:301251)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
