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The N-terminal 24 aa (exon 1) of Ppp2r2b have been replaced with the coding sequence for beta-gal (lacZ) and a neomycin cassette surrounded by two loxP sites followed by a polyadenylation signal to terminate the transcript. A correctly targeted mouse was crossed with a Cre deleter mouse to remove the neomycin cassette. The allele is a null allele. Loss of protain product was confirmed by Western blotting PP2A holoenzymes purified from total forebrain. (J:290154)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
