A human codon-optimized hemagglutinin-tagged Cas9 sequence derived from Streptococcus pyogenes was inserted into the Gt(ROSA)26Sor locus with a loxP-flanked puromycin resistance-containing stop cassette preceding the Cas9 sequence. (J:273279)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count