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The targeting vector was designed with, from 5' to 3', a floxed-STOP cassette that contains a neomycin cassette, a constitutively active mutant form of the mouse ret proto-oncogene cDNA, a viral T2A sequence, and a human histone H2B fused to a constitutively active red enhanced green fluorescence protein (tdTomato). The mutation in Ret is found in patients with multiple endocrine neoplasia type 2A. (J:305439)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
