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The targeting vector is designed with, from 5' to 3', a floxed-STOP cassette that contains a neomycin resistance gene, a mutant form of the human ret proto-oncogene (RET) cDNA, a viral T2A sequence, and a human histone H2B fused to a constitutively active red enhanced green fluorescence protein (tdTomato). The altered Ret sequence lacks the RET extracellular domain, which signals independently of GDNF, and is found in some patients with papillary thyroid carcinomas. (J:305439)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
