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Cre recombinase gene is expressed under the control of upstream cis-acting DNA region of the mouse Olfr1507, 2-kb conserved homology region, mouse H element enhancer, which regulates odorant receptor (OR) gene cluster expression and Olfr1507 promoter. Due to the H enhancer activity, the Cre gene, now under the control of the Tg MOR28 promoter, is frequently chosen and activated for transcription in OSNs. The MOR28 promoter cannot be activated when any one of the endogenous OR genes is expressed first, due to OR-mediated negative feedback regulation. (J:167943)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
