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CRISPR/Cas9 technology generated a C to G change at position 254 (c.254C>G) that results in serine to cysteine substitution at amino acid 85 (p.S85C). These mice also have two silent mutations (c.261T>C, p.F87 and C.264C>T, p.N88) which prevent re-cleavage of the repaired allele and remove an MseI restriction endonuclease site, allowing for genotyping. (J:298091)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
