A loxP site was introduced into intron 2 and a loxP and FRT site flanked neomycin resistance gene cassette plus duplicate sequence of the 3' end of exon 10 were inserted downstream of exon 10. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 3-10 floxed. (J:298850)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd-Hprt1b-m3
Targeted
Insertion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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