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A loxP site was introduced into intron 2 and a loxP and FRT site flanked neomycin resistance gene cassette downstream of exon 10. The neo cassette was removed through subsequent flp-mediated recombination; after that, exons 3-10 were deleted through cre-mediated recombination, leaving exons 1, 2 and the duplicated 3' end of exon 10. Northern and Western blot experiments confirmed the absence of mRNA and protein expression from this allele. (J:298850)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
