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The transgene insert encodes a full-length mouse insulin receptor protein cDNA containing an N-terminal 3xFLAG (DYKDDDDK) tagged alpha-subunit and full length beta-subunit as seen in the native mouse Insr gene. The endogenous signal peptide coding sequence was deleted and replaced with a pre-protrypsin (PPT) signal peptide. Thetransgene is placed downstream of the mouse Cd3d enhancer and promoter construct to elicit T-lymphocyte directed transgene over-expression. A human growth hormone (hGH) poly A signal enhances mRNA stability (J:303894)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
