Tg(Cd3d-Insr*)1Mcin

The transgene insert encodes a full-length mouse insulin receptor protein cDNA containing an N-terminal 3xFLAG (DYKDDDDK) tagged alpha-subunit and full length beta-subunit as seen in the native mouse Insr gene. The endogenous signal peptide coding sequence was deleted and replaced with a pre-protrypsin (PPT) signal peptide. Thetransgene is placed downstream of the mouse Cd3d enhancer and promoter construct to elicit T-lymphocyte directed transgene over-expression. A human growth hormone (hGH) poly A signal enhances mRNA stability (J:303894)