Exons 2 to 6 were flanked by loxP sites. A FRT-flanked PGK-neo cassette was inserted upstream of the floxed exons. Flp-mediated recombination removed the selection cassette, leaving exons 2-6 floxed. (J:283622)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count