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EN
The targeting vector replaced exon 1 with a loxP site, splice acceptor, cDNA for exons 1 through 4, polyadenylaiton sequence, FRT-flanked neomycin resistance cassette, loxP site, splice acceptor, and modified exon 1 with the amino acid substitution of glycine with serine at position 12 (G12S). Cre-mediated recombination removed the cDNA allowing for expression of the mutant form. (J:259739)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
