Log In|Sign Up
EN
Guide RNAs (gaagcactgggggagacgca and gtacatgacaccctcaagga) are designed to create a guanine to adenine missense mutation, resulting in an arginine to histidine change at amino acid 47 (R47H). This mutation R47H is homologous to the human R47H SNP shown to correlate with increased risk of late-onset Alzheimer's disease. Ten silent DNA mutations were also introduced. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
