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The phospho-acceptor sites Ser468 and Ser485 located in exon 15 were mutated to alanine (S468A and S485A). A wild-type copy of exon 15 floxed by loxP sites was inserted into intron 14-15 upstream of the exon 15 splice acceptor followed by a polyadenylation signal. A FRT-flanked neomycin selection cassette was inserted into intron 14-15. FlpE-mediated recombination removed the neo cassette. (J:296139)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
