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The first and second coding exons (1 and 2) were targeted with two sgRNAs (5-ccccgatgacttcagtacttggg-3 and 5- cctcagacccggaatacggatttt-3) using CRISPR/Cas9 technology. Five founder mice were created with at least two different size deletions, both including the end of exon 1, intron 1 and the start of exon 2. The pound # sign is used in the allele symbol because which mouse line was used, or if a mixture was used, is not specified. (J:293929)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
