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The targeting vector is designed to insert an FRT-flanked neomycin resistance (neo) cassette downstream of exon 5. Endogenous exon 5 was modified to harbor a guanine to cytosine mutation at codon 181, resulting in a cysteine to serine mutation (C181S). This targeting vector then was used to retarget Nrastm1Tyj inserting C181S in cis to the existing G12Dmutation. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:289386)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
