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The diphtheria toxin receptor (DTR) gene, preceded by an artificial intron and followed by bovine growth hormone gene poly(A) signal sequence, and an FRT site flanked neomycin resistance gene cassette were inserted into the endogenous ATG start codon. The neo cassette was removed through subsequent flp-mediated recombination, leaving a null allele that expresses a gene that causes cell death when exposed to diphtheria toxin. (J:243655)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
