LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exons 4 and 5. The frt-flanked neomycin selection cassette was removed in the germline via FLP-mediated recombination. (J:250501)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count