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CRISPR/cas9 endonuclease-mediated genome editing is used to replace the mouse Ighg1 locus hinge (exon 2), CH2 (exon 3) and CH3 (exon 4) regions with a 902 bp human hinge (exon 2), CH2 (exon 3) and CH3 (exon 4) sequences while preserving the splice junctions. (J:296090)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
