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The last three exons, 6-8, were replaced with the following: a loxP site flanked neomycin resistance gene cassette, exon 8 splice acceptor sequence, IRES sequence, and the lacZ reporter gene. This creates a reporter-knockout allele. The neo cassette was removed through cre-mediated recombination. Lack of mRNA and protein expression from this allele was confirmed. (J:295208)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
