Log In|Sign Up
EN
This transgene consists of a hybrid Thy1 gene in which a 5.7 kb EcoRI-ApaI mouse Thy1a (Thy1.1) gene fragment containing the first 4 exons (including exons 1a and 1b) and part of exon 4 are fused to a 3.4 kb ApaI-EcoRI human THY1 DNA sequence containing the remaining noncoding part of exon 4 plus 3' human flanking sequence. Four lines were generated; T6, T9, T11, and T12. The T12 line contains multiple copies of the transgene and expresses about 6-10x the normal level of Thy1 in the brain. The mature protein resulting from this transgene is completely Thy1a. High levels of hybrid transgene expression is seen in glomerular podocytes. (J:133943)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
